Research Information System
World Academy of Sciences Journal, vol.8, 2026 (Scopus)
Oral squamous cell carcinoma (OSCC) is a prevalent malignancy with a poor prognosis due to late diagnosis, with a 5‑year survival rate of 35‑50%. Patients with Fanconi anemia (FA) exhibit a 500‑700‑fold increased risk of developing OSCC at younger ages. Non‑invasive biomarkers are critical for early detection in high‑risk groups. The present study investigated the salivary expression levels of miR‑34a and the serum levels of survivin, both of which are associated with the PI3K signaling pathway, in patients with OSCC (n=24), patients with FA (n=24) and healthy controls (n=40). The miRNA levels were quantified using reverse transcription‑quantitative PCR, and protein levels were measured using ELISA. Compared to the controls, the patients with OSCC exhibited significantly lower miR‑34a levels (P=0.012), and patients with FA exhib‑ ited a reduced expression of miR‑34a (P=0.014). Survivin levels were elevated in patients with OSCC (P=0.04) and FA (P=0.01) compared to the controls. A negative correlation was identified between miR‑34a and surviving levels (ρ=‑0.52, P=0.005) in patients with OSCC. These findings suggest that miR‑34a and survivin are promising non‑invasive biomarkers for assessing the risk of developing OSCC in patients with FA and OSCC. However, multicenter studies with larger cohorts are warranted to validate these results for clinical surveillance protocols.