Osteogenesis imperfecta patients: phenotype influence on oral hygiene assessment


Demir K., Tuna İnce E. B., Güleç Ç., Aslanger A. D., Öztürk A. P., Özsait Selçuk B. Ş., ...Daha Fazla

2024 FDI World Dental Congress , İstanbul, Türkiye, 12 - 15 Haziran 2024, cilt.74, ss.115

  • Yayın Türü: Bildiri / Özet Bildiri
  • Cilt numarası: 74
  • Doi Numarası: 10.1016/j.identj.2024.07.923
  • Basıldığı Şehir: İstanbul
  • Basıldığı Ülke: Türkiye
  • Sayfa Sayıları: ss.115
  • İstanbul Üniversitesi Adresli: Evet

Özet

AIM or PURPOSE

Osteogenesis Imperfecta (OI) is a genetic disorder that affects type 1 collagen biosynthesis at various levels of genomic alteration, resulting multisystemic effects, including dental effects. This study aims to explore the correlation between phenotype findings and dental caries development, while also assessing oral hygiene awareness in OI cases.

MATERIALS and METHOD

This study was approved by Istanbul University Faculty of Medicine Clinical Research Ethics Committee (Protocol Number 669442-27.12.2021); included 24 index cases diagnosed with OI (9 female, 15 male), 18 affected family members (9 female, 9 male). Data obtained from intraoral evaluations including dental anomalies, malocclusions, palatal depth, DMFT index, tooth brushing frequency, oral hygiene tools used, educational status, smoking habits and treatment history. The data were analyzed using IBM SPSS Statistics (ver. 28.0, Chicago, IL). Statistically significant (p<0.05) and borderline (0.05<p<0.06) values were recorded. The obtained results were compared with the Angle Class-III malocclusion control group and the literature. The relationship between oral hygiene findings and genotype, treatment status was assessed.

RESULTS

In this study, 83.3%(n=35/42) of the cases were Angle class III and 57.1%(n=24/42) had a deep palatal vault. Spearman correlation analysis revealed a correlation between Angle Class-III malocclusion(n=42,rho=0.309,p=0.04), deep palatal vault (n=42,rho=0.301,p=0.04), smoking habits(n=42,rho=0.382,p=0.01), and increasing age(n=42,rho=0.387,p=0.01) with DMFT values.

CONCLUSION(S)

Our study highlights the genetic influence on oral health, emphasizing the interaction between genetic and environmental factors in the complex etiology of dental caries. The DMFT index may be influenced by both malocclusions and etiological factors. These findings will inform more effective preventive health policies and individualized treatment plans.