Association of MDR1 (C3435T) polymorphism and resistance to carbamazepine in epileptic patients from turkey


Ozgon G. O. , Bebek N. , Gul G., Cine N.

EUROPEAN NEUROLOGY, cilt.59, ss.67-70, 2008 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 59
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1159/000109264
  • Dergi Adı: EUROPEAN NEUROLOGY
  • Sayfa Sayıları: ss.67-70

Özet

Background and Aims: We investigated the prevalence of this multidrug resistance 1 gene (MDR1) polymorphism in drug-responsive versus drug-resistant epilepsy patients treated with carbamazepine (CBZ), which is a substrate of this protein. Methods: We genotyped the C3435T variant of MDR1 in 97 patients treated with CBZ monotherapy who had been on stable doses for more than 1 month. Our control group included 174 healthy individuals. Plasma CBZ concentrations were also measured using fluorescence polarization immunoassay. Results: We could not demonstrate any statistically significant relationship with the genotypes among drug-resistant patients (n = 44). The frequency of the homozygous mutant (TT) genotype was 15% in drug-responsive patients, 11.3% in drug-resistant patients and 25.8% in the control group. We also did not observe any significant correlation between the presence of a specific allele and CBZ plasma level/dose index. Conclusion: Our study did not support any significant association between the MDR1 (C3435T) polymorphism and resistance to CBZ in epilepsy patients from Turkey. Copyright (C) 2007 S. Karger AG, Basel.