Successful treatment of non-healing pressure ulcers with topical n-acetyl cysteine

OZKAYA H. M., Bahat G., Tufan A., DOGAN H., BILICEN Z., Karan M. A.

JOURNAL OF WOUND CARE, vol.24, no.12, pp.606-611, 2015 (SCI-Expanded, Scopus)

  • Publication Type: Article / Article
  • Volume: 24 Issue: 12
  • Publication Date: 2015
  • Doi Number: 10.12968/jowc.2015.24.12.606
  • Journal Name: JOURNAL OF WOUND CARE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.606-611
  • Keywords: pressure ulcer, non-healing, n-acetyl cysteine, nursing home, treatment, CONTRAST-INDUCED NEPHROPATHY, CLOMIPHENE CITRATE, IN-VITRO, ACETYLCYSTEINE, OXYGEN
  • Istanbul University Affiliated: Yes

Abstract

Objective: N-acetyl cysteine (NAC) is a thiol compound with antioxidant and vasodilatory properties. It has multiple potential uses-including as an aid to wound healing-supported by varying levels of evidence. Pressure ulcers (PUs) are a major problem affecting older and bed-bound patients, and are associated with significant morbidity, mortality, and health-care costs. We aimed to study whether topical NAC treatment may be useful in non-healing PUs in a prospective case study in two debilitated nursing home residents suffering from a total of three treatment-resistant PUs.