In silico Analysis of Sulpiride, Synthesis, Characterization and In vitro Studies of its Nanoparticle for the Treatment of Schizophrenia


Kecel-Gunduz S. , Budama-Kilinc Y., Cakir-Koc R., Zorlu T., Bıçak B. , Kokcu Y., ...More

CURRENT COMPUTER-AIDED DRUG DESIGN, vol.16, no.2, pp.104-121, 2020 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 16 Issue: 2
  • Publication Date: 2020
  • Doi Number: 10.2174/1573409915666190627125643
  • Journal Name: CURRENT COMPUTER-AIDED DRUG DESIGN
  • Journal Indexes: Science Citation Index Expanded, Scopus, Agricultural & Environmental Science Database, Biotechnology Research Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE
  • Page Numbers: pp.104-121
  • Keywords: Sulpiride, MD, docking, ADME, chitosan nanoparticles, controlled release system, DOPAMINE D-3 RECEPTOR, BLOOD-BRAIN-BARRIER, CHITOSAN NANOPARTICLES, ACCURATE DOCKING, D3 RECEPTOR, GLIDE, RISPERIDONE, INSIGHTS, PROTEIN, MODEL

Abstract

Background: Sulpiride, which has selective dopaminergic blocking activity, is a substituted benzamide antipsychotic drug playing a prominent role in the treatment of schizophrenia, which more selective and primarily blocks dopamine D2 and D3 receptor.