In silico Analysis of Sulpiride, Synthesis, Characterization and In vitro Studies of its Nanoparticle for the Treatment of Schizophrenia
CURRENT COMPUTER-AIDED DRUG DESIGN, vol.16, no.2, pp.104-121, 2020 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 16 Issue: 2
- Publication Date: 2020
- Doi Number: 10.2174/1573409915666190627125643
- Journal Name: CURRENT COMPUTER-AIDED DRUG DESIGN
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Agricultural & Environmental Science Database, Biotechnology Research Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE
- Page Numbers: pp.104-121
- Keywords: Sulpiride, MD, docking, ADME, chitosan nanoparticles, controlled release system, DOPAMINE D-3 RECEPTOR, BLOOD-BRAIN-BARRIER, CHITOSAN NANOPARTICLES, ACCURATE DOCKING, D3 RECEPTOR, GLIDE, RISPERIDONE, INSIGHTS, PROTEIN, MODEL
- Istanbul University Affiliated: Yes
Abstract
Background: Sulpiride, which has selective dopaminergic blocking activity, is a substituted benzamide antipsychotic drug playing a prominent role in the treatment of schizophrenia, which more selective and primarily blocks dopamine D2 and D3 receptor.