In silico Analysis of Sulpiride, Synthesis, Characterization and In vitro Studies of its Nanoparticle for the Treatment of Schizophrenia

Kecel-Gunduz S., Budama-Kilinc Y., Cakir-Koc R., Zorlu T., Bıçak B., Kokcu Y., ...Daha Fazla

CURRENT COMPUTER-AIDED DRUG DESIGN, cilt.16, sa.2, ss.104-121, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 16 Sayı: 2
  • Basım Tarihi: 2020
  • Doi Numarası: 10.2174/1573409915666190627125643
  • Dergi Adı: CURRENT COMPUTER-AIDED DRUG DESIGN
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Agricultural & Environmental Science Database, Biotechnology Research Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.104-121
  • Anahtar Kelimeler: Sulpiride, MD, docking, ADME, chitosan nanoparticles, controlled release system, DOPAMINE D-3 RECEPTOR, BLOOD-BRAIN-BARRIER, CHITOSAN NANOPARTICLES, ACCURATE DOCKING, D3 RECEPTOR, GLIDE, RISPERIDONE, INSIGHTS, PROTEIN, MODEL
  • İstanbul Üniversitesi Adresli: Evet

Özet

Background: Sulpiride, which has selective dopaminergic blocking activity, is a substituted benzamide antipsychotic drug playing a prominent role in the treatment of schizophrenia, which more selective and primarily blocks dopamine D2 and D3 receptor.