Natural killer cells in patients with allergic diseases

Deniz G., VAN DE VEEN W., AKDIS M.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, cilt.132, sa.3, ss.527-535, 2013 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 132 Sayı: 3
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1016/j.jaci.2013.07.030
  • Dergi Adı: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.527-535
  • Anahtar Kelimeler: Natural killer cells, allergic inflammation, NK1, NK2, NK22, HUMAN NK CELLS, T-CELLS, ATOPIC-DERMATITIS, DENDRITIC CELLS, IFN-GAMMA, ACTIVATING RECEPTOR, ADAPTIVE IMMUNITY, PERIPHERAL-BLOOD, GENE-EXPRESSION, INNATE IMMUNITY
  • İstanbul Üniversitesi Adresli: Evet

Özet

Natural killer (NK) cells not only exert cytotoxic activity against tumor cells or infected cells but also act to regulate the function of other immune cells through secretion of cytokines and chemokines or cell contact-dependent mechanisms. NK cells are able to polarize in vitro into 2 functional distinct subsets, NK1 or NK2 cells, which are analogous to the T-cell subsets T(H)1 or T(H)2. In addition, a regulatory NK cell subset has been described that secretes IL-10, shows antigen-specific T-cell suppression, and suppresses IgE production. Although it has been demonstrated that NK cells play important roles in autoimmunity, cancer, transplantation, and pregnancy, the role of NK cells in allergy has not been extensively discussed. This review aims to discuss our understanding of NK cells and NK cell subsets in allergic inflammation and IgE regulation.