The Growth Characteristics of Patients with Noonan Syndrome: Results of Three Years of Growth Hormone Treatment: A Nationwide Multicenter Study.

Siklar, Zeynep; Genens, Mikayir; Poyrazoglu, Şükran; Bas, Firdevs; Darendeliler, Fatma; Bundak, Ruveyde; Aycan, Zehra; Erdeve, Senay; Cetinkaya, Semra; Guven, Ayla; Abali, Saygın; ATAY, Zeynep; Turan, Serap; Kara, Cengiz; Yilmaz, Gulay; Akyurek, Nesibe; ABACI, Ayhan; Celmeli, Gamze; Sari, Erkan; BOLU, Semih; Korkmaz, Huseyin; SIMSEK, Enver; CATLI, Gonul; Buyukinan, Muammer; CAYIR, Atilla; Evliyaoglu, Olcay; Isguven, Pinar; Ozgen, Tolga; Hatipoglu, Nihal; Elhan, Atilla; Berberoglu, Merih

doi:10.4274/jcrpe.3013

The Growth Characteristics of Patients with Noonan Syndrome: Results of Three Years of Growth Hormone Treatment: A Nationwide Multicenter Study.

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Siklar Z., Genens M., Poyrazoglu S., Bas F., Darendeliler F. F., Bundak R., ...More

Journal of clinical research in pediatric endocrinology, vol.8, no.3, pp.305-12, 2016 (SCI-Expanded)

Publication Type: Article / Article
Volume: 8 Issue: 3
Publication Date: 2016
Doi Number: 10.4274/jcrpe.3013
Journal Name: Journal of clinical research in pediatric endocrinology
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
Page Numbers: pp.305-12
Keywords: Noonan syndrome, growth hormone treatment, growth, CLINICAL-FEATURES, CHILDREN, THERAPY, HEIGHT, MUTATIONS, DIAGNOSIS
Istanbul University Affiliated: Yes

Abstract

Objective: Noonan syndrome (NS) is a multisystem disorder, and short stature is its most striking manifestation. Optimal growth hormone (GH) treatment for NS is still controversial. In this study, using a nationwide registration system, we aimed to evaluate the growth characteristics and the clinical features of NS patients in Turkey and their growth response to GH treatment.