Bladder granulocytic sarcoma in a child: case report and literature review

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Tuna R., Karaman S., Oktar T., Anak S., Doğan Ö., Ünüvar A., ...Daha Fazla

TURKISH JOURNAL OF PEDIATRICS, cilt.64, sa.1, ss.152-159, 2022 (SCI-Expanded) identifier identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 64 Sayı: 1
  • Basım Tarihi: 2022
  • Doi Numarası: 10.24953/turkjped.2020.275
  • Dergi Adı: TURKISH JOURNAL OF PEDIATRICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.152-159
  • Anahtar Kelimeler: acute myeloid leukemia, children, granulocytic sarcoma, bladder, treatment, ACUTE MYELOID-LEUKEMIA, MATRIX METALLOPROTEINASES, EXTRAMEDULLARY LEUKEMIA, MONOCYTIC LEUKEMIA, CANCER, TRANSPLANTATION, EXPRESSION, DIAGNOSIS, CNS
  • İstanbul Üniversitesi Adresli: Evet

Özet

Background. Granulocytic sarcoma (GS) is an extramedullary solid tumor composed of immature myeloid cells. GS has been associated with acute myeloid leukemia (AML), myelodysplastic syndromes or myeloproliferative diseases. Although GS can affect various tissues of the human body, it has rarely been reported in other soft tissues such as the breast, gastrointestinal, respiratory and genitourinary tracts. We report a pediatric case diagnosed with granulocytic sarcoma of the bladder and concomitant AML. Case. A twelve-year-old previously healthy girl was admitted to the pediatric urology dinic with a ten-day history of hematuria and pollakiuria. Laboratory examinations revealed anemia, thrombocytopenia and neutrophilic leukocytosis. Bone marrow aspiration results were consistent with acute myeloid leukemia -FAB subtype M2-. Abdominal magnetic resonance imaging (MRI) showed an irregularly bounded 12 cm mass on the right side of the bladder. Transurethral resection (TUR) pathology was consistent with granulocytic sarcoma. After a multimodal treatment approach, complete remission was achieved. Conclusions. Malignant bladder masses are rare causes of macroscopic hematuria in childhood. The diagnostic spectrum is wide, ranging from rhabdomyosarcoma to leukemia involvement. The bladder is a rare site of extramedullary involvement in pediatric patients with AML. Multimodal treatment should be considered on a per-patient basis.