The Safety and the Efficacy of First-line Antiretroviral Treatment Regimens in Children: A Single Center Experience in Turkey
JOURNAL OF PEDIATRIC INFECTION, sa.4, 2018 (ESCI, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Basım Tarihi: 2018
- Doi Numarası: 10.5578/ced.67663
- Dergi Adı: JOURNAL OF PEDIATRIC INFECTION
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
- Anahtar Kelimeler: Toxicity, pediatric, HIV, antiretroviral treatment, resistance
- İstanbul Üniversitesi Adresli: Evet
Özet
Objective: Active antiretroviral therapy refers to the use of a combination of drugs for treating human immune deficiency virus infection with the aim of preventing long-term toxicity. Material and Methods: This study included 27 HIV-infected patients less than 18 years of age, between the years of 2001-2016. Primary outcomes were serious adverse events and virologic response to ART. Results: The mean age of the patients at the time of diagnosis was 69.2 (1-204) months. Twenty-two patients had LPV/r-based regimen as first-line ART, initially. The mean follow-up period was 67.1 (6-192) months. First line therapy was changed in 6 patients. Resistance against antiretroviral drugs was found in four patients. Conclusion: Despite small number of patients, a protease inhibitor-based regime seems to be a good option for children in immune recovery.