Positive Mixed lymphocyte Culture Test Result Due to HLA-DP Mismatch
BALKAN MEDICAL JOURNAL, sa.2, ss.224-226, 2011 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Editöre Mektup
- Basım Tarihi: 2011
- Doi Numarası: 10.5174/tutfd.2009.02852.1
- Dergi Adı: BALKAN MEDICAL JOURNAL
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.224-226
- İstanbul Üniversitesi Adresli: Evet
Özet
Graft Versus Host Disease (GVHD) remains a major cause of morbidity and mortality in allogeneic stem cell transplantation (SCT). The MLC assay has been generally accepted as a standard test for determining HLA-D region compatibility. In this study, the MLC test has been carried out on the related recipient-donor couple who were prepared for allogeneic SCT and were found to be matched for HLA-A, -B, -Cw, DR, DO but not for -DP. The result of the MLC test was positive. We observed that HLA-DP mismatch was responsible for the increased proliferation values in MLC test.