Positive Mixed lymphocyte Culture Test Result Due to HLA-DP Mismatch

Ayna T. K., TOZKIR H., Ciftci H. S., GÜRKAN H., Tekgunduz E., Algunes C., ...More

BALKAN MEDICAL JOURNAL, vol.28, no.2, pp.224-226, 2011 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Editorial Material
  • Volume: 28 Issue: 2
  • Publication Date: 2011
  • Doi Number: 10.5174/tutfd.2009.02852.1
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.224-226
  • Istanbul University Affiliated: Yes


Graft Versus Host Disease (GVHD) remains a major cause of morbidity and mortality in allogeneic stem cell transplantation (SCT). The MLC assay has been generally accepted as a standard test for determining HLA-D region compatibility. In this study, the MLC test has been carried out on the related recipient-donor couple who were prepared for allogeneic SCT and were found to be matched for HLA-A, -B, -Cw, DR, DO but not for -DP. The result of the MLC test was positive. We observed that HLA-DP mismatch was responsible for the increased proliferation values in MLC test.