Positive Mixed lymphocyte Culture Test Result Due to HLA-DP Mismatch

Ayna T. K., TOZKIR H., Ciftci H. S., GÜRKAN H., Tekgunduz E., Algunes C., ...Daha Fazla

BALKAN MEDICAL JOURNAL, cilt.28, sa.2, ss.224-226, 2011 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Editöre Mektup
  • Cilt numarası: 28 Sayı: 2
  • Basım Tarihi: 2011
  • Doi Numarası: 10.5174/tutfd.2009.02852.1
  • Dergi Adı: BALKAN MEDICAL JOURNAL
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.224-226
  • İstanbul Üniversitesi Adresli: Evet

Özet

Graft Versus Host Disease (GVHD) remains a major cause of morbidity and mortality in allogeneic stem cell transplantation (SCT). The MLC assay has been generally accepted as a standard test for determining HLA-D region compatibility. In this study, the MLC test has been carried out on the related recipient-donor couple who were prepared for allogeneic SCT and were found to be matched for HLA-A, -B, -Cw, DR, DO but not for -DP. The result of the MLC test was positive. We observed that HLA-DP mismatch was responsible for the increased proliferation values in MLC test.