Positive Mixed lymphocyte Culture Test Result Due to HLA-DP Mismatch

Ayna T. K. , TOZKIR H., Ciftci H. S. , GÜRKAN H., Tekgunduz E., Algunes C., ...Daha Fazla

BALKAN MEDICAL JOURNAL, cilt.28, ss.224-226, 2011 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 28 Konu: 2
  • Basım Tarihi: 2011
  • Doi Numarası: 10.5174/tutfd.2009.02852.1
  • Sayfa Sayıları: ss.224-226


Graft Versus Host Disease (GVHD) remains a major cause of morbidity and mortality in allogeneic stem cell transplantation (SCT). The MLC assay has been generally accepted as a standard test for determining HLA-D region compatibility. In this study, the MLC test has been carried out on the related recipient-donor couple who were prepared for allogeneic SCT and were found to be matched for HLA-A, -B, -Cw, DR, DO but not for -DP. The result of the MLC test was positive. We observed that HLA-DP mismatch was responsible for the increased proliferation values in MLC test.