Androgen Stimulation of PCA3 and miR-141 and Their Release from Prostate Cancer Cells

Gezer U., Tiryakioglu D., Bilgin E., Dalay N., Holdenrieder S.

CELL JOURNAL, vol.16, no.4, pp.488-493, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 16 Issue: 4
  • Publication Date: 2015
  • Journal Name: CELL JOURNAL
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.488-493
  • Keywords: Androgens, Culture Media, Mirn141 microRNA, Prostate Cancer, Prostate Cancer Antigen 3, BIOMARKERS, ANTIGEN, RNA, DIAGNOSIS, SAMPLES, PLASMA
  • Istanbul University Affiliated: Yes

Abstract

Objective: Prostate cancer antigen 3 (PCA3) and microRNA-141 (miR-141) are emerging molecules in prostate cancer (PCa) pathogenesis and have been shown to be involved in androgen signaling. In this original research, we designed an experimental cell model with androgen-sensitive LNCaP cells to comparatively assess the extent of androgen responsiveness of PCA3-mRNA and miR-141 along with prostate specific antigen (PSA)-mRNA and their release into culture medium. These molecules were also measured in the plasma of the patients with early PCa which is considered to be analogous to androgen-responsive cells.