PROSTATE CANCER AND PROSTATIC DISEASES, vol.22, no.4, pp.569-579, 2019 (SCI-Expanded)
Background Voltage-gated Na+ channels (VGSCs) are functionally upregulated in rat and human prostate cancer (PCa) where channel activity promotes cellular invasiveness in vitro and metastasis in vivo. Ranolazine is a clinically used VGSC inhibitor/anti-anginal drug, which has been shown previously to inhibit breast cancer metastasis in vivo.