Anti-metastatic effect of ranolazine in an in vivo rat model of prostate cancer, and expression of voltage-gated sodium channel protein in human prostate

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Bugan I., Kucuk S., Karagoz Z., FRASER S. P., KAYA H., DODSON A., ...More

PROSTATE CANCER AND PROSTATIC DISEASES, vol.22, no.4, pp.569-579, 2019 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 22 Issue: 4
• Publication Date: 2019
• Doi Number: 10.1038/s41391-019-0128-3
• Journal Name: PROSTATE CANCER AND PROSTATIC DISEASES
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.569-579
• Istanbul University Affiliated: Yes

Abstract

Background Voltage-gated Na+ channels (VGSCs) are functionally upregulated in rat and human prostate cancer (PCa) where channel activity promotes cellular invasiveness in vitro and metastasis in vivo. Ranolazine is a clinically used VGSC inhibitor/anti-anginal drug, which has been shown previously to inhibit breast cancer metastasis in vivo.