Anti-metastatic effect of ranolazine in an in vivo rat model of prostate cancer, and expression of voltage-gated sodium channel protein in human prostate

Bugan I., Kucuk S., Karagoz Z., FRASER S. P., KAYA H., DODSON A., ...Daha Fazla

PROSTATE CANCER AND PROSTATIC DISEASES, cilt.22, sa.4, ss.569-579, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 22 Sayı: 4
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1038/s41391-019-0128-3
  • Dergi Adı: PROSTATE CANCER AND PROSTATIC DISEASES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.569-579
  • İstanbul Üniversitesi Adresli: Evet

Özet

Background Voltage-gated Na+ channels (VGSCs) are functionally upregulated in rat and human prostate cancer (PCa) where channel activity promotes cellular invasiveness in vitro and metastasis in vivo. Ranolazine is a clinically used VGSC inhibitor/anti-anginal drug, which has been shown previously to inhibit breast cancer metastasis in vivo.