Glucocorticoid deficiency causes transcriptional and post-transcriptional reprogramming of glutamine metabolism

Weger, Meltem; Weger, Benjamin; Goerling, Benjamin; Poschet, Gernot; Yildiz, Melek; Hell, Ruediger; Luy, Burkhard; Akcay, Teoman; GÜRAN, TÜLAY; Dickmeis, Thomas; Mueller, Ferenc; Krone, Nils

doi:10.1016/j.ebiom.2018.09.024

Glucocorticoid deficiency causes transcriptional and post-transcriptional reprogramming of glutamine metabolism

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Weger M., Weger B. D., Goerling B., Poschet G., Yildiz M., Hell R., ...More

EBIOMEDICINE, vol.36, pp.376-389, 2018 (SCI-Expanded)

Publication Type: Article / Article
Volume: 36
Publication Date: 2018
Doi Number: 10.1016/j.ebiom.2018.09.024
Journal Name: EBIOMEDICINE
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.376-389
Istanbul University Affiliated: Yes

Abstract

Background: Deficient glucocorticoid biosynthesis leading to adrenal insufficiency is life-threatening and is associated with significant co-morbidities. The affected pathways underlying the pathophysiology of co-morbidities due to glucocorticoid deficiency remain poorly understood and require further investigation.