Complementary roles of surgery and systemic treatment in clear cell renal cell carcinoma

Ingels, Alexandre; Campi, Riccardo; Capitanio, Umberto; Amparore, Daniele; Bertolo, Riccardo; Carbonara, Umberto; ERDEM, Selçuk; Kara, Onder; Klatte, Tobias; Kriegmair, Maximilian; Marchioni, Michele; Mir, Maria; Ouzaid, Idir; Pavan, Nicola; Pecoraro, Angela; Roussel, Eduard; de la Taille, Alexandre

doi:10.1038/s41585-022-00592-3

Complementary roles of surgery and systemic treatment in clear cell renal cell carcinoma

Ingels A., Campi R., Capitanio U., Amparore D., Bertolo R., Carbonara U., ...More

NATURE REVIEWS UROLOGY, vol.19, no.7, pp.391-418, 2022 (SCI-Expanded)

Publication Type: Article / Review
Volume: 19 Issue: 7
Publication Date: 2022
Doi Number: 10.1038/s41585-022-00592-3
Journal Name: NATURE REVIEWS UROLOGY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CINAHL, EMBASE, MEDLINE
Page Numbers: pp.391-418
Istanbul University Affiliated: Yes

Abstract

Standard-of-care management of renal cell carcinoma (RCC) relies on surgery for low-risk localized disease and systemic treatment for poor-prognosis metastatic tumours, but patients with high-risk localized tumours and with metastatic disease that has a good-to-intermediate prognosis are in a grey area for treatment. In this Review, the authors provide a comprehensive overview of the current knowledge on surgery and systemic treatment in the management of metastatic and localized RCC.