Akademik Veri Yönetim Sistemi
VIDEOSURGERY AND OTHER MINIINVASIVE TECHNIQUES, cilt.18, sa.2, ss.351-357, 2023 (SCI-Expanded)
Introduction: The inflammatory response after laparoscopy and laparotomy has been compared in studies in adults, but only a few studies have compared the immune response between laparoscopy and laparotomy in children. Aim: To compare open and laparoscopic appendectomies regarding a new biomarker, suPAR, to evaluate the inflam-matory response.Material and methods: Patients between 3 and 17 years of age who were admitted to the pediatric surgery depart-ment and scheduled for appendectomy due to appendicitis were enrolled in the investigation. The patients were ran-domized to receive either laparoscopic (n = 20) or conventional open appendectomy (n = 20). The primary outcome was a change in preoperative and postoperative suPAR levels. The secondary outcomes were the white blood cell count, lymphocytes, neutrophils, platelets, C-reactive protein level, appendix diameter, symptoms, symptom dura-tion, surgical complications, operative time, rescue analgesics, hospital stay, and family satisfaction.Results: The mean age of the patients undergoing laparoscopic appendectomy was 10.55 & PLUSMN;2.743 (3-17) years. The mean age of the patients undergoing open appendectomy was 11.40 & PLUSMN;3.515 (3-17) years. A statistically signifi-cant difference was found when the postoperative suPAR values between the two groups were compared (p = 0.048). The operative time and hospital stay in the laparoscopic group were significantly shorter than those in the open group (p = 0.001, p = 0.047).Conclusions: Laparoscopic appendectomy is associated with a shorter operative time, a shorter hospital stay, and a smaller inflammatory response caused by surgical stress than open appendectomy. suPAR is an effective marker for comparing postoperative inflammatory stress between open and closed appendectomies.