Akademik Veri Yönetim Sistemi
WIDEOCHIRURGIA I INNE TECHNIKI MALOINWAZYJNE, cilt.18, sa.2, ss.351-357, 2023 (SCI-Expanded)
A b s t r a c t
Introduction: The inflammatory response after laparoscopy and laparotomy has been compared in studies in adults,
but only a few studies have compared the immune response between laparoscopy and laparotomy in children.
Aim: To compare open and laparoscopic appendectomies regarding a new biomarker, suPAR, to evaluate the inflammatory
response.
Material and methods: Patients between 3 and 17 years of age who were admitted to the pediatric surgery department
and scheduled for appendectomy due to appendicitis were enrolled in the investigation. The patients were randomized
to receive either laparoscopic (n = 20) or conventional open appendectomy (n = 20). The primary outcome
was a change in preoperative and postoperative suPAR levels. The secondary outcomes were the white blood cell
count, lymphocytes, neutrophils, platelets, C-reactive protein level, appendix diameter, symptoms, symptom duration,
surgical complications, operative time, rescue analgesics, hospital stay, and family satisfaction.
Results: The mean age of the patients undergoing laparoscopic appendectomy was 10.55 ±2.743 (3–17) years.
The mean age of the patients undergoing open appendectomy was 11.40 ±3.515 (3–17) years. A statistically significant
difference was found when the postoperative suPAR values between the two groups were compared (p = 0.048).
The operative time and hospital stay in the laparoscopic group were significantly shorter than those in the open
group (p = 0.001, p = 0.047).
Conclusions: Laparoscopic appendectomy is associated with a shorter operative time, a shorter hospital stay, and
a smaller inflammatory response caused by surgical stress than open appendectomy. suPAR is an effective marker for
comparing postoperative inflammatory stress between open and closed appendectomies.
Key words: laparoscopic appendectomy, soluble urokinase plasminogen activator receptor, inflammatory response.