Paraoxonase-1 192/55 Polymorphisms and the Risk of Lung Cancer in a Turkish Population

Aksoy-Sagirli P., Cakmakoglu B., Isbir T., Kaytan-Saglam E., Kizir A., Topuz E., ...Daha Fazla

ANTICANCER RESEARCH, cilt.31, sa.6, ss.2225-2229, 2011 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 31 Sayı: 6
  • Basım Tarihi: 2011
  • Dergi Adı: ANTICANCER RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.2225-2229
  • Anahtar Kelimeler: Paraoxonase 1, PON1, polymorphism, lung cancer risk, SNP, XENOBIOTIC GENE POLYMORPHISMS, OXIDATIVE DNA-DAMAGE, SERUM PARAOXONASE, CIGARETTE-SMOKING, MOLECULAR-BASIS, BREAST-CANCER, PON1 55, SUSCEPTIBILITY, ASSOCIATION, REPAIR
  • İstanbul Üniversitesi Adresli: Evet

Özet

Aim: The purpose of the present study was to investigate the possible association of paraoxonase-1 (PON1) 192/55 polymorphisms with lung cancer (LC) risk in a Turkish population. Materials and Methods: A population-based, case-control study was carried out, including 223 patients with LC and 234 controls. The frequencies of PON1 192155 genotypes were compared in patient and control groups using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis. Results: Distribution of PON1 192 R (+) genotype was found to be significantly higher in patients with LC compared to the controls (odds ratio: 1.497, 95% confidence interval: 1.034-2.166). This difference was especially noteworthy in patients with small cell carcinoma and squamous cell carcinoma. Conclusion: This is the first case-control study on the association between PON1 polymorphisms and LC susceptibility in a Turkish population. Our results suggest that PON1 192 polymorphsim is associated with an increased risk of LC in the Turkish population and may be a useful genetic marker for small cell and squamous cell carcinoma.