Naples prognostic score as a predictor of mortality in surgical aortic valve replacement

Erdoğan O., Erdoğan T., Panç C., Gürbak İ., Ertürk M.

Biomarkers in Medicine, cilt.18, sa.15-16, ss.675-683, 2024 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 18 Sayı: 15-16
  • Basım Tarihi: 2024
  • Doi Numarası: 10.1080/17520363.2024.2389035
  • Dergi Adı: Biomarkers in Medicine
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Chemical Abstracts Core, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.675-683
  • Anahtar Kelimeler: mortality, naples prognostic score, severe aortic stenosis, surgical aortic valve replacement
  • İstanbul Üniversitesi Adresli: Hayır

Özet

Aim: Investigating the impact of nutritional and inflammatory status, assessed by the Naples-Prognostic-Score (NPS), on postoperative mortality in 173 older adults undergoing surgical aortic valve replacement(SAVR) for aortic stenosis(AS). Methods: Retrospective study calculating NPS from neutrophils/lymphocytes, lymphocytes/monocytes, total cholesterol and serum albumin. Results: Mean age was 69.39 ± 6.153 with 45.1% females. The post-operative mortality was 23.7% over a follow-up period of 50 ± 31 months. The 1-month mortality rate is 2.89%. High NPS significantly associated with increased mortality; multivariate logistic regression confirmed its independence (odds-ratio:3.494, 95% confidence-interval:1.555–7.849, p = 0.002). NPS cutoff of 2 showed 73.2% sensitivity, 56.8% specificity and area-under-the-curve of 0.758 for predicting all-cause mortality. Kaplan-Meier analysis supported lower NPS correlating with better survival. Conclusion: NPS independently predicts postoperative mortality in SAVR patients.