We aim to ascertain the possible involvement of functional IL10 and TNF-alpha promoter polymorphisms on the susceptibility to Behcet's syndrome (BS), to examine whether IL10 and TNF-alpha genotypes might work synergistically influencing susceptibility to BS. IL10 -1082G/A, -819C/T and -592C/A and TNF -308G/A polymorphisms were analyzed in 102 Turkish patients with BS and 102 healthy subjects by using amplification refractory mutation system-polymerase chain reaction (ARMS-PCR). We have found no significant associations between IL10 -1082G/A, -819C/T, -592C/A, TNF-alpha-308G/A polymorphisms and BS. Also, no significant correlation was found between IL10 GCC, ACC, ATA haplotypes, GCC(+)/ GCC(+), GCC(+)/GCC(-), GCC(-)/GCC(-) genotypes. There was no significant association between combined TNF-alpha/IL10 genotypes and BS. Our study indicates that functional TNF-alpha, IL10 genotypes or combined TNF-alpha, IL10 genotypes do not play a role in BS susceptibility in Turkish BS patients.