Glutathione S-transferase-pi in malignant tissues and plasma of human colorectal and gastric cancers


Dogru-Abbasoglu S. , Mutlu-Turkoglu U., TURKOGLU S., Erbil Y. , BARBAROS U., Uysal M. M. , ...Daha Fazla

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, cilt.128, ss.91-95, 2002 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 128 Konu: 2
  • Basım Tarihi: 2002
  • Doi Numarası: 10.1007/s00432-001-0300-7
  • Dergi Adı: JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
  • Sayfa Sayıları: ss.91-95

Özet

Purpose: In this study, 16 paired samples of colorectal and gastric cancers and adjacent non-neoplastic tissues were analysed for the determination of glutathione S-transferase (GST) activities and the expression of GST-pi. Methods: Western blotting procedure as well as plasma GST-pi levels were used. Results: GST activities were found to be increased in malignant tissues of patient compared with adjacent normal tissues. A significant correlation was detected between GST activity and GST-pi expression in malignant tissues of patients. Plasma GST-pi levels increased in patients compared to aged-matched control subjects. When the patients were grouped according to TNM stage, GST-pi expression in malignant tissues as well as plasma GST-pi levels were higher in patients with more advanced tumor stages. Conclusions: Our results indicate that GST-pi expression in malignant tissues and plasma GST-pi levels in human colorectal and gastric cancers increased depending on the stages of tumor.