Anti-inflammatory and anti-fibrotic effects of sirolimus on bleomycin-induced pulmonary fibrosis in rats
CLINICAL AND INVESTIGATIVE MEDICINE, vol.34, no.6, 2011 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 34 Issue: 6
- Publication Date: 2011
- Journal Name: CLINICAL AND INVESTIGATIVE MEDICINE
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Istanbul University Affiliated: Yes
Abstract
Purpose: Pulmonary fibrosis is a devastating disease with a poor prognosis. Although the diagnosis and pathophysiology of this disease have been better characterized over the past few years, there is no effective therapy for the disease. The aim of this study was to evaluate the anti-inflammatory and anti-fibrotic effects of sirolimus (SRL), which is a potential anti-fibrotic agent, by using bleomycin (BLM)-induced pulmonary fibrosis model in rats.