Role of Oxidative Stress Response and Trehalose Accumulation in the Longevity of Fission Yeast


Palabiyik B. , Ghods F. J.

JUNDISHAPUR JOURNAL OF MICROBIOLOGY, cilt.8, 2015 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 8 Konu: 6
  • Basım Tarihi: 2015
  • Doi Numarası: 10.5812/jjm.8(6)2015.16851
  • Dergi Adı: JUNDISHAPUR JOURNAL OF MICROBIOLOGY

Özet

Background: Glucose is the preferred carbon and energy source in most organisms and plays an active role in the regulation of many biological processes. However, an excess of glucose leads to such undesirable conditions as diabetes and age-related diseases. Since Schizosaccharomyces pombe homologous of many human genes, it offers several advantages for the investigation of the molecular mechanisms underlying human disease and aging studies. We have identified two glucose-repression-resistant mutants (ird5 and ird11) of S. pombe.