Cytotoxic evaluation of some plants against renal cancer cell lines

Mihoğlugil F., Akalgan Aklar D., TOSUN F.

Journal of Research in Pharmacy, vol.29, no.2, pp.585-589, 2025 (ESCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 29 Issue: 2
  • Publication Date: 2025
  • Doi Number: 10.12991/jrespharm.1661047
  • Journal Name: Journal of Research in Pharmacy
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.585-589
  • Keywords: Coronilla varia, Cytotoxic activity, renal cancer, Telekia speciosa
  • Istanbul University Affiliated: Yes

Abstract

In the current study, we evaluated the cytotoxic activities of 21 extracts from 7 plants belonging to 4 families. The dichloromethane, ethyl acetate, and methanol extracts of the plants were screened for their cytotoxic activities on the renal (A498 and U031) cancer cell lines. 8 extracts exhibited more than 50% growth inhibition at a 25 ug/mL concentration on both renal cancer A498 and UO31 cell lines. The highest cytotoxic activity on the renal cancer UO31 cell line was observed for the methanol extract of the aerial parts of Telekia speciosa with 66% inhibition at a 25 ug/mL concentration. The highest cytotoxic activity on the renal cancer A498 cell line was found for the dichloromethane extract of the aerial parts of Coronilla varia with 64% inhibition at a 25 ug/mL concentration.