Synthesis of novel 1,4-naphthoquinone derivatives: antibacterial and antifungal agents

Ibis C., Tuyun A. F., Bahar H., Ayla S., Stasevych M. V., Musyanovych R. Y., ...More

MEDICINAL CHEMISTRY RESEARCH, vol.22, no.6, pp.2879-2888, 2013 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 22 Issue: 6
  • Publication Date: 2013
  • Doi Number: 10.1007/s00044-012-0300-y
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.2879-2888
  • Keywords: Thio and amino substituted, 1,4-naphthoquinones, Antibacterial and antifungal activity, BIOLOGICAL EVALUATION, SOLID-STATE, 5-ARYLAMINO-2-METHYL-4,7-DIOXOBENZOTHIAZOLES, INHIBITORS
  • Istanbul University Affiliated: Yes


A novel series of substituted 1,4-naphthoquinone derivatives was synthesized and evaluated for antibacterial and antifungal activity. The structures of the novel products were characterized by spectroscopic methods. Among the tested compounds, 3a and 9 are the most effective compounds against M. luteum as potent antibacterial and C. tenuis and A. niger as potent antifungal. These two compounds are promising as biologically active compounds.