The effects of tibolone on the human primary glioblastoma multiforme cell culture and the rat C6 glioma model

Altinoz M. A. , Albayrak S. B. , Karasu A. , Sabanci P. A. , Imer M., Bilir A.

NEUROLOGICAL RESEARCH, vol.31, no.9, pp.923-927, 2009 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 31 Issue: 9
  • Publication Date: 2009
  • Doi Number: 10.1179/174313209x383268
  • Title of Journal : NEUROLOGICAL RESEARCH
  • Page Numbers: pp.923-927


Objectives: In the light of recent advances in tumor biology and genetics, we hypothesized that tibolone, an estrogen receptor agonist, may have antiproliferative effects on primary human glioblastoma cells and rat C6 malignant glioma cell lines. We thought that tibolone should exert its antiproliferative effects by augmenting glial cell differentiation through the naive, nonhypermethylated estrogen receptors in the glioma cells.