Influence of Cytokine Gene Polymorphisms on Graft Rejection in Turkish Patients with Renal Transplants from Living Related Donors


Seyhun Y., Mytilineos J., Turkmen A. , Oguz F. , KEKİK Ç. , Ozdilli K., ...More

TRANSPLANTATION PROCEEDINGS, vol.44, no.6, pp.1670-1678, 2012 (Journal Indexed in SCI) identifier identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 44 Issue: 6
  • Publication Date: 2012
  • Doi Number: 10.1016/j.transproceed.2012.05.046
  • Title of Journal : TRANSPLANTATION PROCEEDINGS
  • Page Numbers: pp.1670-1678

Abstract

Background. Certain cytokine gene polymorphisms (CGPs). have been shown to be associated with renal transplant rejection episodes or graft outcomes. We sought to evaluate the relationships between gene polymorphisms and acute rejection episodes (RG, n = 19) versus stable graft function (NRG, n = 71) in transplant recipients compared with healthy control subjects (HCG, n = 150). The follow-up time period was 18 months. Using polymerase chain reaction sequence-specific primers with the Heidelberg kit we genotyped 22 single nucleotide polymorphisms distributed across 13 cytokine and cytokine receptor genes.