Itchiness is the desire for mechanical irritation of the skin and it may result from various dermatological and sometimes neurological diseases. Neurological causes for itch are relatively unknown and frequently overlooked. Here, we report a case of possible acute inflamatory polyradiculopathy who had facial pruritus and diplopia as the initial symptoms. Diagnosis of our patient was delayed because initial diplopia and pruritus complaints were considered as nonspecific and unrelated to the nervous system. We suggest that pruritus may be a remarkable neurological finding especially when it is accompanied by other neurological symptoms.