Tumor necrosis factor gene polymorphisms in Turkish patients with sarcoidosis

SEYHAN E. C., CETINKAYA E., ALTIN S., GUNLUOGLU Z., Demir A., KOKSAL V., ...More

INTERNAL MEDICINE, vol.47, no.9, pp.833-838, 2008 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 47 Issue: 9
  • Publication Date: 2008
  • Doi Number: 10.2169/internalmedicine.47.0703
  • Journal Name: INTERNAL MEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.833-838
  • Istanbul University Affiliated: Yes

Abstract

Background As reported recently, some gene polymorphisms are suspected to determine susceptibility to sarcoidosis and are held responsible for the extent and progression of the disease. Polymorphism at -857 locus of tumor necrosis factor (TNF)-alpha gene is considered to be a predisposition factor in sarcoidosis and held responsible for pathogenesis of the disease. We compared these polymorphisms in healthy Turkish control subjects and Turkish patients with sarcoidosis.