PEDIATRIC NEPHROLOGY, vol.36, no.5, pp.1195-1205, 2021 (Journal Indexed in SCI)
Article / Article
Title of Journal :
Complement, CKD stage 5, Children, C3 glomerulopathy, Predictors, DENSE DEPOSIT DISEASE, MYCOPHENOLATE-MOFETIL, MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS, POSTINFECTIOUS GLOMERULONEPHRITIS, ECULIZUMAB, EXPERIENCE
Background C3 glomerulopathy (C3G) is characterized by heterogeneous clinical presentation, outcome, and predominant C3 accumulation in glomeruli without significant IgG. There is scarce outcome data regarding childhood C3G. We describe clinical and pathological features, treatment and outcomes, and risk factors for progression to chronic kidney disease stage 5 (CKD5) in the largest pediatric series with biopsy-proven C3G.