Clinical characteristics and course of spinal cord involvement in Behcet's disease


Yesilot N., Mutlu M., Gungor O., Baykal B. , Serdaroglu P., Akman-Demir G.

EUROPEAN JOURNAL OF NEUROLOGY, cilt.14, ss.729-737, 2007 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 14 Konu: 7
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1111/j.1468-1331.2007.01754.x
  • Dergi Adı: EUROPEAN JOURNAL OF NEUROLOGY
  • Sayfa Sayıları: ss.729-737

Özet

Parenchymal neurological involvement in Behcet's disease (p-NBD) usually presents with a brainstem syndrome; occasionally spinal cord may also be involved. Files of patients with Behcet's disease and spinal cord involvement were reviewed retrospectively, in comparison with other types of p-NBD. Amongst 216 patients with p-NBD, 24 had spinal cord involvement (11%). Most commonly patients presented with sensory-motor symptoms, sphincter and/or sexual dysfunction evolving over days. Four of 10 patients showed single or multiple cervical and/or dorsal lesions on spinal MRI's and one showed dorsal atrophy. Although the clinical picture was variable, it tended to be severe; seven cases had primary progressive course, 11 cases had a secondary progressive course after initial attack(s), four had attacks with severe residual sequela and two had improvement after attacks. After a median follow-up period of 67 months, eight were independent and 14 were dead or dependent, whereas amongst the remaining patients with p-NBD, 113 patients were independent and 56 patients were dead or dependent (P < 0.05). Our study suggests that spinal cord involvement has even worse prognosis compared with other types of p-NBD. Therefore, recognition of spinal cord involvement in Behcet's patients should prompt early vigorous treatment.