Expression and cellular distribution of multidrug resistance-related proteins in patients with focal cortical dysplasia


AK H., Ay B. , Tanriverdi T. , Sanus G. Z. , IS M., Sar M., ...More

SEIZURE-EUROPEAN JOURNAL OF EPILEPSY, vol.16, no.6, pp.493-503, 2007 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 16 Issue: 6
  • Publication Date: 2007
  • Doi Number: 10.1016/j.seizure.2007.03.011
  • Title of Journal : SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
  • Page Numbers: pp.493-503

Abstract

Recent arouse of interest indicated that drug resistant proteins are markedly over-expressed in the epileptogenic tissue and they may be responsible for the one-third of the epileptic patients who were refractory to anti-epileptic drugs (AEDs). Since several AEDs may act as substrates for these drug resistant proteins, the enhanced function of such proteins may increase drug extrusion, resulting in inadequate response to drug therapy in patients with epilepsy.