Expression and cellular distribution of multidrug resistance-related proteins in patients with focal cortical dysplasia

AK, Hatil; Ay, Bahadır; Tanriverdi, Taner; Sanus, Galip; IS, Merih; Sar, Mehmet; Oz, Ayşim; Ozkara, Çiğdem; OZYURT, Emin; Uzan, Mustafa

doi:10.1016/j.seizure.2007.03.011

Expression and cellular distribution of multidrug resistance-related proteins in patients with focal cortical dysplasia

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AK H., Ay B., Tanriverdi T., Sanus G. Z., IS M., Sar M., ...More

SEIZURE-EUROPEAN JOURNAL OF EPILEPSY, vol.16, no.6, pp.493-503, 2007 (SCI-Expanded)

Publication Type: Article / Article
Volume: 16 Issue: 6
Publication Date: 2007
Doi Number: 10.1016/j.seizure.2007.03.011
Journal Name: SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.493-503
Istanbul University Affiliated: Yes

Abstract

Recent arouse of interest indicated that drug resistant proteins are markedly over-expressed in the epileptogenic tissue and they may be responsible for the one-third of the epileptic patients who were refractory to anti-epileptic drugs (AEDs). Since several AEDs may act as substrates for these drug resistant proteins, the enhanced function of such proteins may increase drug extrusion, resulting in inadequate response to drug therapy in patients with epilepsy.