Everolimus dosing recommendations for tuberous sclerosis complex-associated refractory seizures

Franz, David; Lawson, John; Yapici, ZÜHAL; Brandt, Christian; Kohrman, Michael; Wong, Michael; Milh, Mathieu; Wiemer-Kruel, Adelheid; Voi, Maurizio; Coello, Neva; Cheung, Wing; Grosch, Kai; French, Jacqueline

doi:10.1111/epi.14085

Everolimus dosing recommendations for tuberous sclerosis complex-associated refractory seizures

Franz D. N., Lawson J. A., Yapici Z., Brandt C., Kohrman M. H., Wong M., ...Daha Fazla

EPILEPSIA, cilt.59, sa.6, ss.1188-1197, 2018 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 59 Sayı: 6
Basım Tarihi: 2018
Doi Numarası: 10.1111/epi.14085
Dergi Adı: EPILEPSIA
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.1188-1197
İstanbul Üniversitesi Adresli: Evet

Özet

ObjectiveThe present analysis examined the exposure-response relationship by means of the predose everolimus concentration (C-min) and the seizure response in patients with tuberous sclerosis complex-associated seizures in the EXIST-3 study. Recommendations have been made for the target C-min range of everolimus for therapeutic drug monitoring (TDM) and the doses necessary to achieve this target C-min.