Everolimus dosing recommendations for tuberous sclerosis complex-associated refractory seizures
EPILEPSIA, vol.59, no.6, pp.1188-1197, 2018 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 59 Issue: 6
- Publication Date: 2018
- Doi Number: 10.1111/epi.14085
- Journal Name: EPILEPSIA
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.1188-1197
- Istanbul University Affiliated: Yes
Abstract
ObjectiveThe present analysis examined the exposure-response relationship by means of the predose everolimus concentration (C-min) and the seizure response in patients with tuberous sclerosis complex-associated seizures in the EXIST-3 study. Recommendations have been made for the target C-min range of everolimus for therapeutic drug monitoring (TDM) and the doses necessary to achieve this target C-min.