Everolimus dosing recommendations for tuberous sclerosis complex-associated refractory seizures

Franz D. N. , Lawson J. A. , Yapici Z. , Brandt C., Kohrman M. H. , Wong M., ...More

EPILEPSIA, vol.59, no.6, pp.1188-1197, 2018 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 59 Issue: 6
  • Publication Date: 2018
  • Doi Number: 10.1111/epi.14085
  • Title of Journal : EPILEPSIA
  • Page Numbers: pp.1188-1197


ObjectiveThe present analysis examined the exposure-response relationship by means of the predose everolimus concentration (C-min) and the seizure response in patients with tuberous sclerosis complex-associated seizures in the EXIST-3 study. Recommendations have been made for the target C-min range of everolimus for therapeutic drug monitoring (TDM) and the doses necessary to achieve this target C-min.