Everolimus dosing recommendations for tuberous sclerosis complex-associated refractory seizures

Franz D. N., Lawson J. A., Yapici Z., Brandt C., Kohrman M. H., Wong M., ...Daha Fazla

EPILEPSIA, cilt.59, sa.6, ss.1188-1197, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 59 Sayı: 6
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1111/epi.14085
  • Dergi Adı: EPILEPSIA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1188-1197
  • İstanbul Üniversitesi Adresli: Evet

Özet

ObjectiveThe present analysis examined the exposure-response relationship by means of the predose everolimus concentration (C-min) and the seizure response in patients with tuberous sclerosis complex-associated seizures in the EXIST-3 study. Recommendations have been made for the target C-min range of everolimus for therapeutic drug monitoring (TDM) and the doses necessary to achieve this target C-min.