Akademik Veri Yönetim Sistemi
ONCOLOGY IN CLINICAL PRACTICE, 2025 (ESCI, Scopus)
Introduction. Small cell lung cancer (SCLC) is one of the most common malignant causes of superior vena cava syndrome (SVCS). Still, the clinical consequences of this syndrome have yet to be fully understood. In this study, the aim was to determine the clinical significance of SVCS in patients with SCLC. Material and methods. A total of 374 SCLC patients were retrospectively investigated and evaluated. Results. Small cell lung cancer was present in 24 (6.4%) patients at the time of diagnosis. In SVCS patients, all tumors were located in the right lung (p = 0.0001); most were in the upper lobes (n = 19, p = 0.009); and a greater number of tumors were larger than 5 cm (n = 21, p = 0.002). No correlation was found between the presence of SVCS and other clinical parameters, such as age, gender, weight loss, performance status, clinical stage, metastasis pattern, chemotherapy response, and recurrence. Overall survival rates were found to be similar in patients with and without SVCS (p = 0.1). Conclusions. While tumor location and size were found to be associated with SVCS in SCLC patients, SVCS was not found to have prognostic value in terms of survival.