The weight and ghrelin changes of fecal microbiota transplantation in rats

Idiz C., Bektasoglu H., Celikten M., Nayci A. E., Okmen H., Idiz U. O., ...More

PROGRESS IN NUTRITION, vol.20, no.3, pp.520-525, 2018 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 20 Issue: 3
  • Publication Date: 2018
  • Doi Number: 10.23751/pn.v20i3.7492
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.520-525
  • Istanbul University Affiliated: Yes


Background: Fecal microbiota transplantation is a promising method to solve obesity. Our study's aim was to investigate the changes of weight and ghrelin levels in obese rats receiving fecal microbiota transplantation from lean rats. Methodology: Twenty-one rats were divided into three equal groups: Group 1: Obese control group; group 2: Obese recipient group; and group 3: Lean donor group. Feces which was collected from donor group was transferred to the rats in recipient group, orally by gavage, 3 times every other day. The weight and ghrelin levels were measured from each rat at the beginning and end of the study. Results: There was statistically significant weight gain in donor group (p: 0.001), but there were no statistical significant weight chances was detected in control and recipient groups (p: 0.82, p: 0.12, respectively). There was an increase in donor and control groups, but a decrease was observed in the recipient group at ghrelin levels. However, there was no significant difference at ghrelin levels in any groups (p: 0.05, p: 0.2, p: 0.4, respectively). There was a significant relation in control group in weight and ghrelin changes (p: 0.007), but no significant relation was detected in either recipient or donor groups (p: 0.29, 0.53, respectively). Conclusion: Metabolism changes of obese rats were observed after fecal microbiota transplantation, and it was the only group that decreasing ghrelin levels.