INCREASED CHITOTRIOSIDASE ACTIVITIES IN PATIENTS WITH RHEUMATOID ARTHRITIS: A POSSIBLE NOVEL MARKER?

Basok B. I., Kucur M., Kizilgul M., Yilmaz I., Ekmekci O. B., Uzunlulu M., ...Daha Fazla

JOURNAL OF MEDICAL BIOCHEMISTRY, cilt.33, sa.3, ss.245-251, 2014 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 33 Sayı: 3
  • Basım Tarihi: 2014
  • Doi Numarası: 10.2478/jomb-2014-0010
  • Dergi Adı: JOURNAL OF MEDICAL BIOCHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.245-251
  • İstanbul Üniversitesi Adresli: Evet

Özet

Background: Chitotriosidase and YKL-40 are well-known in humans as Glyco_18 domain-containing proteins that are the common feature of mammalian chitinases and chitinase-like proteins. Previously, increased levels of YKL-40 were found correlated with the disease activity of rheumatoid arthritis. However, serum chitotriosidase activity in rheumatoid arthritis is not known yet. The aim of this study was to determine YKL-40 and chitotriosidase in patients with rheumatoid arthritis and to compare these markers with traditional ones such as C-reactive protein and erythrocyte sedimentation rate.