Comparison of the effects of chronic intra-articular administration of tenoxicam, diclofenac, and methylprednisolone in healthy rats

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ORAK M. M., AK D., Midi A., Lacin B., Purisa S., BULUT G.

ACTA ORTHOPAEDICA ET TRAUMATOLOGICA TURCICA, vol.49, no.4, pp.438-446, 2015 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 49 Issue: 4
• Publication Date: 2015
• Doi Number: 10.3944/aott.2015.14.0312
• Journal Name: ACTA ORTHOPAEDICA ET TRAUMATOLOGICA TURCICA
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
• Page Numbers: pp.438-446
• Istanbul University Affiliated: Yes

Abstract

Objective: Lyophilized drug manufacturing and intra-articular (IA) applications have increased to address gastrointestinal side effects resulting from chronic treatment with non-steroidal anti-inflammatory drugs (NSAIDs) for degenerative joint disease. Accordingly, we histologically examined joint and stomach tissues from rats to determine and compare the effects of long-term treatment with an IA corticosteroid (methylprednisolone acetate), lyophilized NSAID (tenoxicam), and non-lyophilized NSAID (diclofenac) following application to the knee joint.