Comparison of the effects of chronic intra-articular administration of tenoxicam, diclofenac, and methylprednisolone in healthy rats


ORAK M. M. , AK D., Midi A., Lacin B., Purisa S. , BULUT G.

ACTA ORTHOPAEDICA ET TRAUMATOLOGICA TURCICA, vol.49, no.4, pp.438-446, 2015 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 49 Issue: 4
  • Publication Date: 2015
  • Doi Number: 10.3944/aott.2015.14.0312
  • Title of Journal : ACTA ORTHOPAEDICA ET TRAUMATOLOGICA TURCICA
  • Page Numbers: pp.438-446

Abstract

Objective: Lyophilized drug manufacturing and intra-articular (IA) applications have increased to address gastrointestinal side effects resulting from chronic treatment with non-steroidal anti-inflammatory drugs (NSAIDs) for degenerative joint disease. Accordingly, we histologically examined joint and stomach tissues from rats to determine and compare the effects of long-term treatment with an IA corticosteroid (methylprednisolone acetate), lyophilized NSAID (tenoxicam), and non-lyophilized NSAID (diclofenac) following application to the knee joint.