Current approach to cutaneous mastocytosis in childhood.

Tamay Z. Ü., Ozceker D.

Turk pediatri arsivi, cilt.51, sa.3, ss.123-127, 2016 (Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 51 Sayı: 3
  • Basım Tarihi: 2016
  • Doi Numarası: 10.5152/turkpediatriars.2016.2418
  • Dergi Adı: Turk pediatri arsivi
  • Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.123-127
  • Anahtar Kelimeler: Child, cutaneous, mastocytosis, BLOOD MONONUCLEAR-CELLS, C-KIT, MAST-CELLS, PEDIATRIC MASTOCYTOSIS, PERIPHERAL-BLOOD, URTICARIA-PIGMENTOSA, CATALYTIC DOMAIN, CHILDREN, MUTATIONS
  • İstanbul Üniversitesi Adresli: Evet

Özet

Mastocytosis is a heterogeneous disorder characterized by clonal proliferation and accumulation of mast cells in one of more organs which may lead to different clinical pictures. Pathological increase and activation of mast cells in various tissues can cause different clinical pictures. Cutaneous mastocytosis limited to the skin is the most typical clinical picture observed in children and systemic mastocytosis is very rare in the pediatric age group. The diagnosis of cutaneous mastocytosis is based on clinical findings, but is often delayed due to lack of clinical awareness of the disease and lack of its consideration in the differential diagnosis. This article focuses on the current diagnosis, management and treatment of cutaneous mastocytosis in children in order to increase awareness about this issue.