IS A MODIFIED BFM REGIMEN WITH 1 Gram/m2 METHOTREXATE AS EFFECTIVE AS 5 Gram/m2 IN PEDIATRIC ADVANCED-STAGE NONLYMPHOBLASTIC NON-HODGKIN LYMPHOMA?

Kebudi R., Yıldırım U., Şenol B., Zulfikar B.

LEUKEMIA RESEARCH, cilt.121, ss.41, 2022 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 121
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1016/s0145-2126(22)00251-x
  • Dergi Adı: LEUKEMIA RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.41
  • İstanbul Üniversitesi Adresli: Evet

Özet

We study the dynamics of island nucleation in the presence of adsorbates using kinetic Monte Carlo simulations of a two-species growth model. Adatoms (A-atoms) and impurities (B-atoms) are codeposited, diffuse and aggregate subject to attractive AA- and AB-interactions. Activated exchange of adatoms with impurities is identified as the key process to maintain decoration of island edges by impurities during growth. While the presence of impurities strongly increases the island density, a change in the scaling of island density with flux, predicted by a rate equation theory for attachment-limited growth [D. Kandel, Phys. Rev. Lett. 78, 499 (1997)], is not observed. We argue that, within the present model, even completely covered island edges do not provide efficient barriers to attachment.