Influence of aging on blood-brain barrier permeability and free radical formation following experimental brain cold injury

Erdincler P., Tuzgen S., Erdincler U., Oguz E., Korpinar A., Ciplak N., ...Daha Fazla

ACTA NEUROCHIRURGICA, cilt.144, sa.2, ss.195-200, 2002 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 144 Sayı: 2
  • Basım Tarihi: 2002
  • Doi Numarası: 10.1007/s007010200024
  • Dergi Adı: ACTA NEUROCHIRURGICA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.195-200
  • İstanbul Üniversitesi Adresli: Hayır

Özet

The aim of this study is to investigate the effects of experimental cold brain injury on blood-brain barrier integrity, on brain oedema formation, and on lipid peroxidation and to compare the results between the aged and young rats. Cold brain injury was used to create a standard model of brain trauma in old and young rats. Disruption of the blood-brain barrier was analyzed by Evans blue method. Them values of cerebral water content were calculated by using the fresh and dry weights of the cerebral hemispheres. Lipid peroxidation was assessed by measuring the tissue content of malonyl dialdehyde.