Neuroprotective effects of GYKI 52466 on experimental spinal cord injury in rats

Colak A., Soy O., Uzun H., Aslan O., Barut S., Belce A., ...Daha Fazla

JOURNAL OF NEUROSURGERY, cilt.98, sa.3, ss.275-281, 2003 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 98 Sayı: 3
  • Basım Tarihi: 2003
  • Doi Numarası: 10.3171/spi.2003.98.3.0275
  • Dergi Adı: JOURNAL OF NEUROSURGERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.275-281
  • İstanbul Üniversitesi Adresli: Evet

Özet

Object. The toxic effects of glutamate in the central nervous system are well known. This neurotoxicity occurs through metabotropic and ionotropic receptors, the latter group composed of N-methyl-D-aspartate, alpha-amino-3hydroxy-5-methylisoxazole-4-proprionic acid (AMPA), and kainate receptors. The authors investigated the neuroprotective effects of GYKI 52466, a 2,3-benzodiazepine that is a selective and potent AMPA receptor antagonist, in a rat spinal cord trauma model.