Neuroprotective effects of GYKI 52466 on experimental spinal cord injury in rats


Colak A., Soy O., Uzun H. , Aslan O., Barut S., Belce A. , ...Daha Fazla

JOURNAL OF NEUROSURGERY, cilt.98, ss.275-281, 2003 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 98 Konu: 3
  • Basım Tarihi: 2003
  • Doi Numarası: 10.3171/spi.2003.98.3.0275
  • Dergi Adı: JOURNAL OF NEUROSURGERY
  • Sayfa Sayıları: ss.275-281

Özet

Object. The toxic effects of glutamate in the central nervous system are well known. This neurotoxicity occurs through metabotropic and ionotropic receptors, the latter group composed of N-methyl-D-aspartate, alpha-amino-3hydroxy-5-methylisoxazole-4-proprionic acid (AMPA), and kainate receptors. The authors investigated the neuroprotective effects of GYKI 52466, a 2,3-benzodiazepine that is a selective and potent AMPA receptor antagonist, in a rat spinal cord trauma model.