Akademik Veri Yönetim Sistemi
Archives of Epilepsy, cilt.32, sa.1, ss.9-14, 2026 (ESCI, Scopus, TRDizin)
Objective: Post-traumatic epilepsy (PTE) is a significant sequela of traumatic brain injury (TBI), with a high incidence of drug-resistant epilepsy. The role of prophylactic antiseizure medications (ASM) remains controversial. This study investigates the demographic, clinical, radiological, and electrophysiological characteristics of PTE and evaluates the impact of ASM use. Methods: We retrospectively analyzed patients diagnosed with PTE at Istanbul University, Istanbul Faculty of Medicine Hospital (1994-2024). Clinical characteristics, imaging findings, electroencephalography results, and ASM use were assessed. Statistical analyses were conducted to explore correlations between trauma severity, epilepsy latency, and ASM efficacy. Results: There were 67 patients diagnosed with PTE, 73 Conclusion: ASM fails to prevent epileptogenesis and should not be routinely prescribed for seizure prophylaxis in patients with TBI. Trauma severity is a critical predictor of epilepsy onset and drug resistance. The presence of bilateral MRI lesions warrants closer monitoring. Given the complex consequences of TBI, these patients should be closely monitored by multidisciplinary teams.