Sesquiterpene Coumarin Ethers and Phenylpropanoids from the Roots of <i>Ferula drudeana</i>, the Putative Anatolian Ecotype of the Silphion Plant

KURAN F. K., Senadeera S. P. D., Wang D., Hwang J., Goncharova E., Wilson J., ...More

MOLECULES, vol.30, no.9, 2025 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 30 Issue: 9
  • Publication Date: 2025
  • Doi Number: 10.3390/molecules30091916
  • Journal Name: MOLECULES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, Biotechnology Research Abstracts, CAB Abstracts, Chemical Abstracts Core, Communication Abstracts, Food Science & Technology Abstracts, MEDLINE, Metadex, Veterinary Science Database, Directory of Open Access Journals, Civil Engineering Abstracts
  • Istanbul University Affiliated: Yes

Abstract

Four new sesquiterpene coumarin ethers (1-4) and a new phenylpropanoid compound (5) were isolated from a hexane extract of the roots of Ferula drudeana, the putative Anatolian ecotype of the silphion plant, in addition to nineteen previously described sesquiterpene coumarins (6-24) and four known phenylpropanoid derivatives (25-28). The structures of these compounds were elucidated by extensive spectroscopic analysis and computational studies. The cytotoxic activities of all isolated compounds were evaluated on renal, malignant pleural mesothelioma (MPM) and colon cancer cell lines. While 11 sesquiterpene coumarin derivatives showed strong-to-moderate cytotoxic activity against the UO31 renal cancer cell line, 13 compounds showed strong cytotoxic activity against the MPM cell line, and four sesquiterpene coumarin derivatives displayed moderate cytotoxic activity against the colon cancer cell line.