Upregulation of T-Cell-Specific Transcription Factor Expression in Pediatric T-Cell Acute Lymphoblastic Leukemia (T-ALL).

Sayitoglu, Müge; Erbilgin, Yücel; Ng, Özden; Yildiz, Inci; Celkan, Tülin; Anak, Sema; Devecioglu, Omer; AYDOGAN, Gonul; Karaman, Serap; SARPER, Nazan; Timur, Cetin; URE, Umit; Ozbek, Ugur

doi:10.5505/tjh.2012.13540

Upregulation of T-Cell-Specific Transcription Factor Expression in Pediatric T-Cell Acute Lymphoblastic Leukemia (T-ALL).

Sayitoglu M., Erbilgin Y., Ng O. H., Yildiz I., Celkan T., Anak S., ...Daha Fazla

Turkish journal of haematology : official journal of Turkish Society of Haematology, cilt.29, sa.4, ss.325-33, 2012 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 29 Sayı: 4
Basım Tarihi: 2012
Doi Numarası: 10.5505/tjh.2012.13540
Dergi Adı: Turkish journal of haematology : official journal of Turkish Society of Haematology
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
Sayfa Sayıları: ss.325-33
İstanbul Üniversitesi Adresli: Evet

Özet

Objective: T-cell acute lymphoblastic leukemia (T-ALL) is associated with recurrent chromosomal aberrations and abnormal ectopic gene expression during T-cell development. In order to gain insight into the pathogenesis of T-ALL this study aimed to measure the level of expression of 7 T-cell oncogenes (LMO2, LYL1, TAL1, TLX1, TLX3, BMI1, and CALM-AF10) in pediatric T-ALL patients.