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in: Medical and Dental Aspects of Anaerobes, Duerden BI, Wade WG, Brazier JS,Elley A,Wren B, Hudson MJ, Editor, Science Reviews, Essex, pp.295-305, 1995
The aim of this study was to evaluate the local effect of spiramycin 0.5% gel prepared with sodium carbozymethylcellulose on subgingival microflora and periodontal tissues in 10 patients with adults periodontitis. The effect of spiramycin gel was coppared with that of a spiramycin-free placebo gel at two pairs of contralateral sites with periodontal destruction in each subject. The gels were applied to periodontal poctes once a week for 4 consecutive weeks. The periodontal sites were examined clinically and microbiologically for a period of 7 weeks. The clinical examination included assesments of plaque index (PI),sulcus bleeding index(SBI),probing pocket depth (PPD) and attachment level (AL).Total bacterial denisty and the density of back-pigmented gram-negative anaerobes(Porphyromonas and Prevotella) was determined bu culture.Significant differences were found between spiramycin and placebo groups in SBI values up to 7 weeks(p<0.05). Total bacterial density and the density of back-pigmanted gram-negative anaerobes in the periodontal pockets were significantly decreased 8p>0.05) at the fourth and seventh weeks when compared with the pretreatment values. The extent of the decrease in the total bacterial density at the seventh week was signifivant compared with the placebo group (p<0.05).