Reduced Orexin-A Levels in Frontotemporal Dementia: Possible Association With Sleep Disturbance

Coban A., Bilgic B., Lohmann E., Kucukali C. I., Benbir G., Karadeniz D., ...Daha Fazla

AMERICAN JOURNAL OF ALZHEIMERS DISEASE AND OTHER DEMENTIAS, cilt.28, sa.6, ss.606-611, 2013 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 28 Sayı: 6
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1177/1533317513494453
  • Dergi Adı: AMERICAN JOURNAL OF ALZHEIMERS DISEASE AND OTHER DEMENTIAS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.606-611
  • Anahtar Kelimeler: orexin-A, frontotemporal dementia, sleep disturbances, polysomnography, plasma, EXCESSIVE DAYTIME SLEEPINESS, MULTIPLE-SYSTEM ATROPHY, PARKINSONS-DISEASE, ALZHEIMERS-DISEASE, HYPOCRETIN-1 LEVELS, LEWY BODIES, CSF OREXIN, TASK-FORCE, NARCOLEPSY, DEGENERATION
  • İstanbul Üniversitesi Adresli: Evet

Özet

Sleep disturbances including excessive daytime sleepiness (EDS) are encountered in frontotemporal dementia (FTD). To investigate the relationship between the plasma orexin-A levels and sleep disturbance patterns, we measured the plasma orexin-A levels and performed sleep studies in patients with FTD. The orexin-A levels were measured in 10 consecutive patients with FTD and controls by enzyme-linked immunosorbent assay. Nocturnal polysomnography (PSG) and Multiple Sleep Latency Test (MSLT) were performed in 2 patients with FTD. The orexin-A levels were significantly lower in patients with FTD compared to controls. The PSG revealed increased rapid eye movement (REM) latency in patients, whether or not they reported EDS. Mean sleep latency in MSLT was less than 10 minutes in both the patients, being shorter in patient without EDS, but none of them had REM sleep onset. Some patients with FTD may develop narcolepsy-like involuntary sleep attacks, even without complaining of EDS. Involvement of hypothalamus and a subsequent alteration in the orexin levels might be one of the determining factors in this sleep disturbance.