Akademik Veri Yönetim Sistemi
FLORA INFEKSIYON HASTALIKLARI VE KLINIK MIKROBIYOLOJI DERGISI, cilt.27, sa.1, ss.55-64, 2022 (Hakemli Dergi)
Introduction: It was aimed to evaluate the risk factors for the development of ventilator-associated pneumonia (VAP) and clinical
outcomes and prognostic predictors of VAP.
Materials and Methods: This retrospective and single-center study included patients aged ≥18 years who were diagnosed with VAP
in the ICU. Patients were divided into two groups with VAP or without VAP. Univariable and multivariable analyses were used to assess
risk factors and prognostic predictors of VAP.
Results: A total of 177 patients were evaluated. Mean length of intensive care unit (ICU) stay and the duration of mechanical ventilation was longer in patients with VAP than in patients without VAP [29 (3-107) vs. 12 (3-70) days, 22 (3-90) vs. 10 (3-45) days; p<
0.001]. Rectal colonization with carbapenem-resistant Klebsiella pneumoniae (CRKp) was found to be higher in the VAP group compared to the non-VAP group (n= 41, 58% vs. n= 25, 24%, p< 0.001). Ventilation period (OR= 1.07; 95% CI 1.02-1.12, p= 0.003),
smoking (OR= 3.89; 95% CI 1.68-8.9, p= 0.001), and rectal colonization with CRKp (OR= 4.93; 95% CI 2.09-11.64, p< 0.001)
were detected as independent risk factors for the development of VAP. Age (OR= 1.15; 95% CI 1.03-1.28, p= 0.01), SOFA score (OR=
1.60; 95% CI 1.05-2.43, p= 0.02) and rectal colonization with CRKp (OR= 15.2; 95% CI 2.33-99.01, p= 0.004) were detected as
independent risk factors for mortality in patients with VAP