Akademik Veri Yönetim Sistemi
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2023 (SCI-Expanded)
Lyotropic liquid crystal nanoparticles (LLCNs), including lipid-based structures, are one of the crucial candidate molecules for drug delivery applications due to several advantages in terms of low toxicity, high loading ca-pacity, and superior pharmacokinetic properties. Generally, in literature, monoglycerides such as glyceryl monostearate are preferred lipids to produce LLCNs. However, lyotropic mesophases have previously been ob-tained by the incorporation of diglycerides with monoglycerides. In this study, glyceryl monostearate and glyceryl dibehenate mixtures are used as lipid compartments to produce LLCNs while Pluronic F-127 (F-127) was used as the surfactant with two methods for the first time in literature. Oil in water (o/w) and film preparation-rehydration methods were used to produce LLCNs with different lipid-to-surfactant (L:S) ratios. It was shown that L3:S7 and L7:S3 ratios provide obtaining LLCNs using the film preparation-rehydration method. Curcumin, which was used as a model hydrophobic drug was incorporated in L3:S7:C1 and L7:S3:C1 ratios. The formation of lyotropic mesophases was tracked using a Polarizing Optical Microscope (POM) and Small-Angle X-ray Scattering (SAXS). The size of the formed nanoparticles (NP) was measured using Dynamic Light Scattering (DLS) and the particles with sizes less than 300 nm namely L7:S3 and L7:S3:C1 were chosen as the optimized particles for drug delivery. The incorporation of the LLCN components was studied using FT-IR and Differential Scanning Chalorimetry (DSC) methods. It was successfully demonstrated that both curcumin and F-127 are completely covered by the lipid components of the formed LLCNs, which altogether resulted in obtaining NPs with Maltese crosses and hexagonal structures.