Preoperative Levels of Matrix Metalloproteinase-7 and-9 and Tissue Inhibitor of Matrix Metalloproteinase-1 Relation to Pathologic Parameters in Bladder Carcinoma Patients

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Atıf İçin Kopyala

Gunes M., Kemik A. S., Pirincci N., Gecit I., Taken K., Yuksel M. B., ...Daha Fazla

ASIAN PACIFIC JOURNAL OF CANCER PREVENTION, cilt.14, sa.2, ss.873-876, 2013 (SCI-Expanded)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 14 Sayı: 2
• Basım Tarihi: 2013
• Doi Numarası: 10.7314/apjcp.2013.14.2.873
• Dergi Adı: ASIAN PACIFIC JOURNAL OF CANCER PREVENTION
• Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Sayfa Sayıları: ss.873-876
• İstanbul Üniversitesi Adresli: Evet

Özet

Our aim was to test the hypothesis that preoperative serum levels of matrix metalloproteinase-7 (MMP-7) and -9 (MMP-9) and tissue inhibitor of matrix metalloproteinase (TIMP-1) levels correlate with pathological features. Serum levels of MMP-7, and MMP-9 and TIMP-1 were determined in 90 bladder cancer patients and 40 healthy controls using an enzyme linked immunosorbent assay. Preoperative serum MMP-7 and MMP-9 levels were significantly higher in cancer patients than control groups (p<0.001). In contast, serum TIMP-1 levels were lower (p<0.001). Alteration in MMP-7, and MMP-9, and TIMP-1 production may contribute to tumor angiogenesis and be associated with clinic-pathological features.