Cotinus coggygria Scop.: A study on the Investigation of in vitro Antioxidant Activity and Prevention of Ethanol-induced Rat Brain Damage
Cumhuriyet Science Journal, cilt.47, sa.4, ss.629-639, 2026 (TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 47 Sayı: 4
- Basım Tarihi: 2026
- Doi Numarası: 10.17776/csj.1912522
- Dergi Adı: Cumhuriyet Science Journal
- Derginin Tarandığı İndeksler: TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.629-639
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- İstanbul Üniversitesi Adresli: Evet
Özet
Cotinus coggygria Scop. (C. coggygria) has been reported to contain numerous secondary metabolites. In the present study, in vitro total phenolic and flavonoid contents and antioxidant activity of C. coggygria extract were determined. In in vivo experiments, rats were divided into four groups. Total oxidant and antioxidant status, nitric oxide, reduced glutathione, lipid peroxidation, sialic acid, advanced oxidized protein product levels and carbonic anhydrase, aryl esterase, xanthine oxidase, lactate dehydrogenase, paraoxonase, prolidase, acetylcholinesterase enzyme activities and antioxidant and glutathione-related enzyme activities were determined in all brain tissue homogenates. According to the results, aqueous C. coggygria extract shows protective properties against ethanol-induced brain damage due to various bioactive components it contains and provides restoration of biochemical parameters. Considering the data from our study, C. coggygria can be used to prevent ethanol-induced oxidative stress in brain tissue due to its strong antioxidant activity.