Complementary Role of Ga-68-Prostate-Specific Membrane Antigen and F-18-FDG PET/CT for Evaluation of Metastases and Treatment Response in Renal Cell Carcinoma

Has Simsek D., Civan C., Erdem S., Sanli Y.

CLINICAL NUCLEAR MEDICINE, cilt.46, sa.7, ss.579-581, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Editöre Mektup
  • Cilt numarası: 46 Sayı: 7
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1097/rlu.0000000000003590
  • Dergi Adı: CLINICAL NUCLEAR MEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.579-581
  • Anahtar Kelimeler: F-18-FDG, Ga-68-PSMA, PET/CT, renal cell carcinoma
  • İstanbul Üniversitesi Adresli: Evet

Özet

We present a case of clear cell renal cell carcinoma, which demonstrates complementary FDG and prostate-specific membrane antigen (PSMA) uptake on metastases in PET/CT, as an example of tumor heterogeneity. The patient had non-FDG-avid lung and bone metastases with PSMA uptake, whereas metastatic cervical and axillary lymph nodes showed vice versa, and skeletal muscle metastasis to vastus lateralis, which is an unusual region for metastasis, showed both PSMA and FDG positivity. In response assessment, mix response was detected. It seems that Ga-68-PSMA and F-18-FDG may have a complementary role in demonstration of metastasis accurately and assessment of treatment response in clear cell renal cell carcinoma.