Antitumor Efficacy of Ceranib-2 with Nano-Formulation of PEG and Rosin Esters

Ben Taleb A., KARAKUŞ S., TAN E., İLGAR M., KUTLU Ö., Gozuacik D., ...Daha Fazla

SUPRAMOLECULES IN DRUG DISCOVERY AND DRUG DELIVERY, cilt.2207, ss.199-220, 2021 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 2207
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1007/978-1-0716-0920-0_16
  • Dergi Adı: SUPRAMOLECULES IN DRUG DISCOVERY AND DRUG DELIVERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Biotechnology Research Abstracts, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.199-220
  • Anahtar Kelimeler: Ceranib-2, Rosin ester, PEGylation, Nanoencapsulation, Anticancer, SMART DRUG-DELIVERY, SPHINGOLIPID METABOLISM, BIODEGRADABLE POLYMERS, CELL-SURVIVAL, GLOBAL BURDEN, CANCER, CERAMIDE, PEGYLATION, STRESS, SPHINGOSINE-1-PHOSPHATE
  • İstanbul Üniversitesi Adresli: Evet

Özet

Ceranib-2 is a recently discovered, poorly water-soluble potent ceramidase inhibitor, with the ability to suppress cancer cell proliferation and delay tumor growth. However, its poor water solubility and weak cellular bioavailability hinder its use as a therapeutic agent for cancer. PEGylated rosin esters are an excellent platform as a natural polymer for drug delivery applications, especially for controlling drug release due to their degradability, biocompatibility, capability to improve solubility, and pharmacokinetics of potent drugs. In this study, stable aqueous amphiphilic submicron-sized PEG400-rosin ester-ceranib-2 (PREC-2) particles, ranging between 100 and 350 nm in a 1:1 mixture, were successfully synthesized by solvent evaporation mediated by sonication.